Education
MS Ecole Nationale Superieure de Chimie de Lille, France
Bio
DNA-mitomycins adducts formation. Synthesis and NMR characterization.
Detection of drugs of abuse by NMR spectroscopy.
Molecular modeling.
Scholarly Work
Δ: indicates a John Jay undergraduate student.
║: Indicates a student in the Master of Forensic Sciences.
1-Aguilar, W.Δ, Paz, M. M., Vargas, A.Δ, Zheng, M. Δ, Cheng, S.Y., & Champeil, E.* (2018). Interdependent sequence-selectivity and diastereoselectivity in the alkylation of DNA by decarbamoylmitomycin C. Chemistry a European Journal, 24 (50), 13278-13289. Impact Factor: 5.16. 1 citation.
2-Zacarias, O. Δ, Aguilar, W. Δ, Paz, M. M., Tsukanov, S. Δ, Zheng, M. Δ, Cheng, S.Y., Pradhan, P., & Champeil, E.* (2018). Isolation and rationale for the formation of isomeric decarbamoylmitomycin C-N6-deoxyadenosine adducts in DNA. Chemical Research in Toxicology, 31 (8), 762-771. Impact Factor: 3.432.
3-Cheng, S. Y.*, Vargas, A.Δ, Lee, J. -Y. Δ, Clement, C. C.*, & Champeil, E.* (2018). Involvement of Akt in mitomycin C and its analog triggered cytotoxicity in MCF-7 and K562 cancer cells. Chemical Biology and Drug Design, in press, 1-13, http://dx.doi.org/10.1111/cbdd.13374. Impact Factor: 2.328.
4-Aguilar, W.Δ, Paz, M. M., Vargas, A.Δ, Clement, C. C., Cheng, S.Y., & Champeil, E.* (2018). Sequence-dependent diastereospecific and diastereodivergent crosslinking of DNA by decarbamoylmitomycin C” Chemistry a European Journal, 24 (23), 6030-6035. Impact factor: 5.16. 2 citations
5-Napolitano, T. Δ, Cheng, S.Y., Nielsen, B. Δ, Choi, C. Δ, Aguilar, W. Δ, Paz, M.M., Sapse, A.M., & Champeil, E.* (2017). Acetone promoted 1,4-migration of an alkoxycarbonyl group on a syn-1,2-diamine. Tetrahedron Letters, 58 (7), 597-601. Impact factor: 2.377.
6-Cheng, S. Y.*, Seo, J.Δ, Huang, B.T.Δ, Napolitano, T.Δ, & Champeil, E.* (2016). Mitomycin C and decarbamoyl mitomycin C induce p53-independent p21WAF1/CIP1 activation. International Journal of Oncology, 49 (5), 1815-1824. Impact factor: 3.333. 6 citations
7-Bose, A., Surugihalli, C., Pande, P., Champeil, E., & Basu A. K.* (2016). Comparative error-free and error-prone translesion synthesis of the N2 -2'-deoxyguanosine adducts formed by mitomycin C and its metabolite, 2,7-diaminomitosene, in human cells. Chemical Research in Toxicology, 29 (5), 933-939. Impact factor: 3.432. 6 citations.
8-Champeil, E.*, Cheng, S. Y.*, Huang, B.T.Δ, Conchero-Guisan, M., Martinez, T. Δ, Paz, M.M., & Sapse, A.M. (2016). Synthesis of Mitomycin C and Decarbamoylmitomycin C N2 deoxyguanosine-adducts. Bioorganic Chemistry, 65, 90-99. Impact factor: 3.929. 4 citations.
9-Mouzi, L., Adams, O.║, Cuff, G., Lukasiewicz, E.Δ, Champeil, E., & Atchabahian, A.* (2016). Plasma concentrations of ropivacaine following ultrasound-guided or nerve-stimulator-guided femoral nerve block: A prospective randomized study. Anaesthesia Critical Care and Pain Medicine, 35 (1), 45-48. Impact factor: 2.200. 1 citation.
10-Champeil, E.*, & Sapse, A.M (2014). Synthesis of a mitomycin C-lexitropsin hybrid. Comptes Rendus Chimie, 17 (12), 1190-1196. Impact factor: 1.877. 2 citations
11-Champeil, E.*, Paz, M. M., Lukasiewicz, E.Δ, Kong, W.Δ, Watson, S.Δ, & Sapse, A.M. (2012). Synthesis of a major mitomycin C DNA adduct via a triaminomitosene. Bioorganic and Medicinal Chemistry Letters, 22 (23), 7198-7200. Impact factor: 2.442. 3 citations.
12-Lesar, C.T.║, Decatur, J., Luckasiewicz, E.Δ, & Champeil, E.* (2011). Identification of gamma-hydroxybutyric acid (GHB) and gamma-butyrolactone (GBL) in beverages using NMR and the PURGE solvent-suppression technique. Forensic Science International, 212 (1-3), 40-45. Impact factor: 1.974. 16 citations.
13-Sapse, D., Champeil, E.*, & Sapse, A.M. (2011). Theoretical calculations applied to the study of the energetics of reactions of methamphetamine synthesis. Comptes Rendus Chimie, 14 (5), 503-510. Impact factor: 1.877. 2 citations.
14-Invited review: Bargonetti, J., Champeil, E., & Tomasz, M.* (2010). Differential toxicity of DNA adducts of mitomycin C. Journal of Nucleic Acids, available on line. DOI:10.4061/2010/698960. 33 citations.
15-Weng, M.-W., Zheng, Y., Jasti, V.P., Champeil, E., Tomasz, M., Wang, Y., Basu, A. K., & Tang, M.-S* (2010). Repair of mitomycin C mono- and interstrand cross-linked DNA adducts by UvrABC: a new model. Nucleic Acid Research, 38 (20), 6976-6984. Impact factor: 11.561. 40 citations.
16-Liu, J.║, Proni, G., & Champeil, E.* (2010) Identification and quantitation of 3,4-methylenedioxy-N-methylamphetamine (MDMA, ecstasy) in human urine by 1H NMR spectroscopy. Application to five cases of intoxication. Forensic Science International, 194 (1-3), 103-107. Impact factor: 1.974. 17 citations.
17-Champeil, E.*, Proni,G., & Sapse, D. S. (2009) Ab Initio studies of receptor interactions with AMPA ((S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl) propionic acid) and kainic acid (2S-(2α, 3β, 4β))-2-carboxy-9-(1-methylethenyl)-3-pyrrolidineacetic acid. Journal of Molecular Modeling, 15 (9), 1109-1117. Impact factor: 1.507. 1 citation.
18-Paz, M. M., Ladwa, S., Champeil, E., Tang, L.-Q., Rockwell, S., Boamah, E., Bargonetti-Chavarria, J., Callahan, J., Roach, J., & Tomasz, M.* (2008) Mapping DNA adducts of mitomycin C and decarbamoyl mitomycin C in cell lines using liquid chromatography/ electrospray tandem mass spectrometry. Chemical Research in Toxicology, 21 (12), 2370-2378. Impact factor: 3.432. 23 citations.
19-Sapse, D. S., Champeil, E., Maddaluno, J., Fressigné, C., & Sapse, A. M.* (2008) Ab initio study of the interaction of DNA fragments with methyllithium. Comptes Rendus Chimie, 11 (10), 1262-1270. Impact factor: 1.877. 5 citations.
20-Champeil, E.*, Paz, M. M., Ladwa, S., Clement, C., Zatorski, A., & Tomasz, M.* (2008) Synthesis of an oligodeoxyribonucleotide adduct of Mitomycin C by the postoligomerization method via a triamino mitosene. Journal of the American Chemical Society, 130 (29), 9556-9565. Impact factor: 14.357. 14 citations.
21-Champeil, E., Crean, C., Larraya, C., Pesticelli, G., Proni, G., & Ghosez, L.* (2008) Functionalization of C60 via organometallic reagents. Tetrahedron, 64 (45), 10319-10330. Impact factor: 2.377. 26 citations.
22-Champeil, E., Pradham, P., & Lakshman, M. K.* (2007) Palladium-catalyzed synthesis of nucleoside adducts from bay and fjord region diol epoxides. Journal of Organic Chemistry, 72 (14), 5035-5045. Impact factor: 4.805. 15 citations.
23-Champeil, E., & Draper, S. M.* (2001) Ferrocenylalkynes as ligands in transition metal complexes. Journal of the Chemical Society, Dalton Transactions, 9, 1440-1447. Impact factor: 4.099. 19 citations.
24-Draper, S. M.*, Delamesiere, M., Champeil, E., Twamley, B., Byrne, J. J., & Long, C. (1999) Novel acetylene-linked di-cobalt and tetra-cobalt carbonyl clusters” Journal of Organometallic Chemistry, 589 (2), 157-167. Impact factor: 1.946. 31 citations.
25-Braga, D., Draper, S. M., Champeil, E., & Grepioni, F.* (1999) Inorganic-organometallic crystal synthesis. The role of charge-assisted C-H…O and C-H…Cl hydrogen bonds in crystalline [(C5H5)2Co][H2PO4].3H2O and [(C6H5Me)2Cr][Cl]. Journal of Organometallic Chemistry, 573 (1-2), 73-77. Impact factor: 1.946. 44 citations.
26-O’Callaghan, C. N., McMurry, T. B. H.*, Draper, S. M., & Champeil, E. (1999) Nitrile and non-nitrile pyridine products from the reaction of 2-cyano-3-(X-nitrophenyl)prop-2-enamides with methyl 3-oxobutanoate. Journal of chemical research (S), 12, 690-691. Impact factor: 0.646.
Book Chapter
Champeil, E. (2012). Magnetic resonance spectroscopy: a powerful tool for the identification and quantitation of drugs and drugs of abuse in biofluids. In D. Sapse & L. Kobilinsky (Eds), Forensic Science Advances and Their Application in the Judiciary System (pp.113-131). Boca Raton, FL: CRC press, Taylor and Francis group.
