Education
Bio
DNA-mitomycins adducts formation. Synthesis and NMR characterization.
Detection of drugs of abuse by NMR spectroscopy.
Molecular modeling.
Course Taught
CHE 201 and 202
SCI 166
FOS 402
Languages spoken/fluent in
Scholarly Work
Peer reviewed journals (27 papers and 1 invited review. 24 publications are affiliated with John Jay College)
Journals Impact Factors (IF) are from the Journal Citation Reports (JCR).
Δ: indicates a John Jay undergraduate student. Highlighted in yellow.
║: Indicates a student in the Master of Forensic Sciences. Highlighted in grey.
1- Aguilar, W.Δ, Zacarias, O. Δ, Romaine, M.Δ, Proni, G., Petrovic, A. G., Abzalimov, R., Paz, M. M. & Champeil, E.* (2020). Synthesis of Oligonucleotides containing the cis-Interstrand Crosslink Produced by Mitomycins in their Reaction with DNA. Chemistry a European Journal, accepted. Impact Factor: 5.16. Paper selected as Hot paper (very important paper) and selected for an inside cover.
2-Zheng, M. Δ, Hwang, S. Δ, Snyder, T Δ, Aquilina, J. Δ, Proni. G. , Paz, M. M., Pradhan, P., Cheng, S.Y., & Champeil, E.* (2019). Synthesis of Mitomycin C and Decarbamoylmitomycin C N2 deoxyguanosine-adducts. Bioorganic Chemistry, 92, 2019. 103280-103290. Impact factor: 3.926 https://doi.org/10.1016/j.bioorg.2019.103280
3-Aguilar, W.Δ, Paz, M. M., Vargas, A.Δ, Zheng, M. Δ, Cheng, S.Y., & Champeil, E.* (2018). Interdependent sequence-selectivity and diastereoselectivity in the alkylation of DNA by decarbamoylmitomycin C. Chemistry a European Journal, 24 (50), 13278-13289. Impact Factor: 5.16. 1 citation.
4-Zacarias, O. Δ, Aguilar, W. Δ, Paz, M. M., Tsukanov, S. Δ, Zheng, M. Δ, Cheng, S.Y., Pradhan, P., & Champeil, E.* (2018). Isolation and rationale for the formation of isomeric decarbamoylmitomycin C-N6-deoxyadenosine adducts in DNA. Chemical Research in Toxicology, 31 (8), 762-771. Impact Factor: 3.432.
5-Cheng, S. Y.*, Vargas, A.Δ, Lee, J. -Y. Δ, Clement, C. C.*, & Champeil, E.* (2018). Involvement of Akt in mitomycin C and its analog triggered cytotoxicity in MCF-7 and K562 cancer cells. Chemical Biology and Drug Design, 92 (6), 2022-2034. Impact Factor: 2.328.
6-Aguilar, W.Δ, Paz, M. M., Vargas, A.Δ, Clement, C. C., Cheng, S.Y., & Champeil, E.* (2018). Sequence-dependent diastereospecific and diastereodivergent crosslinking of DNA by decarbamoylmitomycin C” Chemistry a European Journal, 24 (23), 6030-6035. Impact factor: 5.16. 2 citations.
7-Napolitano, T. Δ, Cheng, S.Y., Nielsen, B. Δ, Choi, C. Δ, Aguilar, W. Δ, Paz, M.M., Sapse, A.M., & Champeil, E.* (2017). Acetone promoted 1,4-migration of an alkoxycarbonyl group on a syn-1,2-diamine. Tetrahedron Letters, 58 (7), 597-601. Impact factor: 2.377.
8-Cheng, S. Y.*, Seo, J.Δ, Huang, B.T.Δ, Napolitano, T.Δ, & Champeil, E.* (2016). Mitomycin C and decarbamoyl mitomycin C induce p53-independent p21WAF1/CIP1 activation. International Journal of Oncology, 49 (5), 1815-1824. Impact factor: 3.333. 6 citations.
9-Bose, A., Surugihalli, C., Pande, P., Champeil, E., & Basu A. K.* (2016). Comparative error-free and error-prone translesion synthesis of the N2 -2'-deoxyguanosine adducts formed by mitomycin C and its metabolite, 2,7-diaminomitosene, in human cells. Chemical Research in Toxicology, 29 (5), 933-939. Impact factor: 3.432. 6 citations.
10-Champeil, E.*, Cheng, S. Y.*, Huang, B.T.Δ, Conchero-Guisan, M., Martinez, T. Δ, Paz, M.M., & Sapse, A.M. (2016). Synthesis of Mitomycin C and Decarbamoylmitomycin C N2 deoxyguanosine-adducts. Bioorganic Chemistry, 65, 90-99. Impact factor: 3.929. 4 citations.
11-Mouzi, L., Adams, O.║, Cuff, G., Lukasiewicz, E.Δ, Champeil, E., & Atchabahian, A.* (2016). Plasma concentrations of ropivacaine following ultrasound-guided or nerve-stimulator-guided femoral nerve block: A prospective randomized study. Anaesthesia Critical Care and Pain Medicine, 35 (1), 45-48. Impact factor: 2.200. 1 citation.
12-Champeil, E.*, & Sapse, A.M (2014). Synthesis of a mitomycin C-lexitropsin hybrid. Comptes Rendus Chimie, 17 (12), 1190-1196. Impact factor: 1.877. 2 citations.
13-Champeil, E.*, Paz, M. M., Lukasiewicz, E.Δ, Kong, W.Δ, Watson, S.Δ, & Sapse, A.M. (2012). Synthesis of a major mitomycin C DNA adduct via a triaminomitosene. Bioorganic and Medicinal Chemistry Letters, 22 (23), 7198-7200. Impact factor: 2.442. 3 citations.
14-Lesar, C.T. ║, Decatur, J., Luckasiewicz, E.Δ, & Champeil, E.* (2011). Identification of gamma-hydroxybutyric acid (GHB) and gamma-butyrolactone (GBL) in beverages using NMR and the PURGE solvent-suppression technique. Forensic Science International, 212 (1-3), 40-45. Impact factor: 1.974. 16 citations.
15-Sapse, D., Champeil, E.*, & Sapse, A.M. (2011). Theoretical calculations applied to the study of the energetics of reactions of methamphetamine synthesis. Comptes Rendus Chimie, 14 (5), 503-510. Impact factor: 1.877. 2 citations.
16-Invited review: Bargonetti, J., Champeil, E., & Tomasz, M.* (2010). Differential toxicity of DNA adducts of mitomycin C. Journal of Nucleic Acids, available on line. DOI:10.4061/2010/698960. 33 citations.
17-Weng, M.-W., Zheng, Y., Jasti, V.P., Champeil, E., Tomasz, M., Wang, Y., Basu, A. K., & Tang, M.-S* (2010). Repair of mitomycin C mono- and interstrand cross-linked DNA adducts by UvrABC: a new model. Nucleic Acid Research, 38 (20), 6976-6984. Impact factor: 11.561. 40 citations.
18-Liu, J.║, Proni, G., & Champeil, E.* (2010) Identification and quantitation of 3,4-methylenedioxy-N-methylamphetamine (MDMA, ecstasy) in human urine by 1H NMR spectroscopy. Application to five cases of intoxication. Forensic Science International, 194 (1-3), 103-107. Impact factor: 1.974. 17 citations.
19-Champeil, E.*, Proni,G., & Sapse, D. S. (2009) Ab Initio studies of receptor interactions with AMPA ((S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl) propionic acid) and kainic acid (2S-(2α, 3β, 4β))-2-carboxy-9-(1-methylethenyl)-3-pyrrolidineacetic acid. Journal of Molecular Modeling, 15 (9), 1109-1117. Impact factor: 1.507. 1 citation.
20-Paz, M. M., Ladwa, S., Champeil, E., Tang, L.-Q., Rockwell, S., Boamah, E., Bargonetti-Chavarria, J., Callahan, J., Roach, J., & Tomasz, M.* (2008) Mapping DNA adducts of mitomycin C and decarbamoyl mitomycin C in cell lines using liquid chromatography/ electrospray tandem mass spectrometry. Chemical Research in Toxicology, 21 (12), 2370-2378. Impact factor: 3.432. 23 citations.
21-Sapse, D. S., Champeil, E., Maddaluno, J., Fressigné, C., & Sapse, A. M.* (2008) Ab initio study of the interaction of DNA fragments with methyllithium. Comptes Rendus Chimie, 11 (10), 1262-1270. Impact factor: 1.877. 5 citations.
22-Champeil, E.*, Paz, M. M., Ladwa, S., Clement, C., Zatorski, A., & Tomasz, M.* (2008) Synthesis of an oligodeoxyribonucleotide adduct of Mitomycin C by the postoligomerization method via a triamino mitosene. Journal of the American Chemical Society, 130 (29), 9556-9565. Impact factor: 14.357. 14 citations.
23-Champeil, E., Crean, C., Larraya, C., Pesticelli, G., Proni, G., & Ghosez, L.* (2008) Functionalization of C60 via organometallic reagents. Tetrahedron, 64 (45), 10319-10330. Impact factor: 2.377. 26 citations.
24-Champeil, E., Pradham, P., & Lakshman, M. K.* (2007) Palladium-catalyzed synthesis of nucleoside adducts from bay and fjord region diol epoxides. Journal of Organic Chemistry, 72 (14), 5035-5045. Impact factor: 4.805. 15 citations.
25-Champeil, E., & Draper, S. M.* (2001) Ferrocenylalkynes as ligands in transition metal complexes. Journal of the Chemical Society, Dalton Transactions, 9, 1440-1447. Impact factor: 4.099. 19 citations.
26-Draper, S. M.*, Delamesiere, M., Champeil, E., Twamley, B., Byrne, J. J., & Long, C. (1999) Novel acetylene-linked di-cobalt and tetra-cobalt carbonyl clusters” Journal of Organometallic Chemistry, 589 (2), 157-167. Impact factor: 1.946. 31 citations.
27-Braga, D., Draper, S. M., Champeil, E., & Grepioni, F.* (1999) Inorganic-organometallic crystal synthesis. The role of charge-assisted C-H…O and C-H…Cl hydrogen bonds in crystalline [(C5H5)2Co][H2PO4].3H2O and [(C6H5Me)2Cr][Cl]. Journal of Organometallic Chemistry, 573 (1-2), 73-77. Impact factor: 1.946. 44 citations.
28-O’Callaghan, C. N., McMurry, T. B. H.*, Draper, S. M., & Champeil, E. (1999) Nitrile and non-nitrile pyridine products from the reaction of 2-cyano-3-(X-nitrophenyl)prop-2-enamides with methyl 3-oxobutanoate. Journal of chemical research (S), 12, 690-691. Impact factor: 0.646.
Book Chapter
Champeil, E. (2012). Magnetic resonance spectroscopy: a powerful tool for the identification and quantitation of drugs and drugs of abuse in biofluids. In D. Sapse & L. Kobilinsky (Eds), Forensic Science Advances and Their Application in the Judiciary System (pp.113-131). Boca Raton, FL: CRC press, Taylor and Francis group.
Research Summary
Elise Champeil is a bio-organic chemist and recently made two significant discoveries regarding anti-cancer drugs currently used in the clinics; mitomycins. She determined that Mitomycins, which work by "alkylating" DNA, target GpC DNA sequences in addition to the well-known CpG target sequences. Continuing from that research, she developed a synthetic route to access a type of adduct (Interstrand Crosslinks) that mitomycins produce when they react with DNA. She is now investigating the cellular responses triggered by the Interstrand Crosslinks generated by these drugs. She is particularly interested in determining how the structure of the DNA lesions caused by the drugs influences cellular signalling. She has mentored over 37 undergrduate students (13 have been admitted to graduate schools) and 10 graduate students (Msc.). She has been the recipient of two SCORE NIH grants.
