Elise Champeil

Elise Champeil

Associate Professor
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 PhD     Trinity College, University of Dublin, Ireland 
MS       Ecole Nationale Superieure de Chimie de Lille, France


Research interests include:
DNA-mitomycin C adducts formation. Synthesis and NMR characterization.
Detection of drugs of abuse by NMR spectroscopy.
Molecular modeling.
Fullerene chemistry.
Synthesis of molecular sensors.




Publications (Total number of published journal publications: 16, conference proceedings: 8, invited chapter: 1, invited presentations: 5)


Peer Reviewed Articles:


1- Champeil E., Paz M., Lukasiewicz E., Kong W., Watson  S., Sapse A.M.“Synthesis of a major mitomycin C DNA adduct via a triaminomitosene”. Bioorganic and Medicinal Chemistry Letters, 22, 2012 7198.

2- Lesar C.T., Decatur J., Luckasiewicz E., Champeil E.“Identification of Gamma-Hydroxybutyric acid (GHB) and Gamma-Butyrolactone (GBL) in beverages using NMR and the PURGE solvent-suppression technique”. Forensic Science International, 212, 2011 40.

3-Sapse D., Champeil E., Sapse A.M. “Theoretical Calculations Applied to the study of the energetics of Reactions of Methamphetamine Synthesis”, Compte rendu des Séances de l’Académie Francaise, 14, 2011 503.

4-Bargonetti J., Champeil E., Tomasz M. “Differential toxicity of DNA adducts of Mitomycin C”, Journal of Nucleic Acids, 2010 Article ID 698960, available on line. DOI:10.4061/2010/698960.

5- Weng M-W, Zheng Y., Jasti V.P., Champeil E., Tomasz M., Wang Y., Basu A.K., Tang M.-S. “Repair of mitomycin C mono- and interstrand cross-linked DNA adducts by UvrABC: a new model”, Nucleic Acid Research, 38, 2010 6976.

6- Liu J., Proni G., Champeil E. “Identification and quantitation of 3,4-methylenedioxy-N-methylamphetamine (MDMA, ecstasy) in human urine by 1H NMR spectroscopy. Application to five cases of intoxication”, Forensic Science International, 194, 2010 103.

7-Champeil E., Proni G., Sapse D. S.“Ab Initio studies of receptor interactions with AMPA ((S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl) propionic acid ) and kainic acid (2S-(2?,3ß,4ß))-2-carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid”  Journal of Molecular Modeling, 15, 2009 1109.

8-Paz M., Ladwa S., Champeil E., Tang L.-Q., Rockwell S., Boamah E., Bargonetti-Chavarria J., Callahan J., Roach J., Tomasz M. “Mapping DNA adducts of mitomycin C and decarbamoyl mitomycin C in cell lines using liquid chromatography/ electrospray tandem mass spectrometry” Chemical Research in Toxicology, 21, 2008 2370.

9-Champeil E., Crean C., Larraya C., Pesticelli G., Proni G., Ghosez L. “Functionalization of C60 via organometallic reagents” Tetrahedron, 64, 2008 10319.

10- Sapse D. S., Champeil E., Maddaluno J., Fressigne C., Sapse A.-M. Ab initio study of the interaction of DNA fragments with methyllithiumCompte rendu des Séances de l’Académie Francaise, 11, 2008 1262.

11- Champeil E., Paz M., Ladwa S., Clement C., Zatorski A., Tomasz M. “Synthesis of an Oligodeoxyribonucleotide Adduct of Mitomycin C by the Postoligomerization Method via a Triamino Mitosene” Journal of American Society, 130, 2008 9556.
12- Champeil E., Pradham P., Lakshman M. K. “Palladium-catalyzed Synthesis of Nucleoside adducts from Bay and Fjord Region Diol epoxides” Journal of Organic Chemistry, 72, 2007 5035.

13- Champeil E., Draper S. M. “Ferrocenylalkynes as ligands in transition metal complexes”

Journal of the Chemical  Society, Dalton Transaction, 9, 2001 1440.

14-Braga D., Draper S. M., Champeil E., Grepioni F. “Inorganic-organometallic crystal synthesis. The role of charge-assisted C-H…O and C-H…Cl hydrogen bonds in crystalline [(C5H5)2Co][H2PO4].3H2O and [(C6H5Me)2Cr][Cl] ”Journal of Organometallic Chemistry, 573, 1999 73.

15-Draper S. M., Delamesiere M., Champeil E., Twamley B., Byrne J. J., Long C. “Novel acetylene-linked di-cobalt and tetra-cobalt carbonyl clusters” Journal of Organometallic Chemistry, 589, 1999 157.

16-O’Callaghan C. N., McMurry T. B. H., Draper S. M., Champeil E. “Nitrile and non-nitrile pyridine products from the reaction of 2-cyano-3-(X-nitrophenyl)prop-2-enamides with methyl 3-oxobutanoate” Journal of chemical research-S, 1999 690A.



Champeil E.Fighting the War on Drugs: What Weapons for Analysis and Detection?”  Journal of Forensic Toxicology and Pharmacology” 2012, 1:1


Scholarly Book Chapter:

“Magnetic resonance spectroscopy: a powerful tool for the identification and quantitation of drugs of abuse in bio-fluids”

Title of the book “Advances in Forensic Science and Application to Law ”. CRC publishers. Editors : Lawrence Kobilinsky, Danielle Sapse. 2012.



Synthetic Organic Chemistry

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